A Research Assistant position is available at the Institute of Biomedicine to investigate mitochondrial DNA replication and its role in disease. The project examines molecular effects of pathogenic mutations in mitochondrial replication factors and identifies small molecules that influence replication. The work includes recombinant protein expression and purification, cloning, in vitro mutagenesis, and DNA replication studies using reconstituted systems with radiolabeled nucleotides. The role involves close collaboration within an international research environment focused on understanding cellular mechanisms and improving diagnostics and treatments for mitochondrial-related diseases.